Article
A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins.
Virology - 10 Oct 1998
Weber F, Kochs G, Gruber S, Haller O
Abstract excerpt
We have previously shown that the nucleoprotein (NP) of Thogoto virus (THOV), a tick-borne member of the Orthomyxoviridae family, accumulates in the cell nucleus. Here we demonstrate that THOV NP contains a motif (KRxxxxxxxxxKTKK) at amino acid positions 179-193 that represents a classical bipartite nuclear localization signal (NLS). This sequence motif (named cNLS) was able to translocate a cytoplasmic 80-kDa...
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