Article
Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice.
Bioscience, biotechnology, and biochemistry - 1 Aug 1998
Islam Z, Nagase M, Ota A, Ueda S, Yoshizawa T, Sakato N
Abstract excerpt
Recently we found that a single administration of T-2 toxin (T-2), a trichothecene mycotoxin, into mice induced DNA fragmentation, a biochemical hallmark of apoptosis, in the thymus. In this study, we investigated the effective chemical structure(s) of T-2-derived metabolites capable of inducing thymic apoptosis in vivo in mice. Metabolic conversion of T-2 to 3'-hydroxy-T-2 toxin (3'-OH-T-2) did not diminish the...
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