Article
Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice.
Bioscience, biotechnology, and biochemistry - 1 Aug 1998
Islam Z, Nagase M, Ota A, Ueda S, Yoshizawa T, Sakato N
Abstract excerpt
Recently we found that a single administration of T-2 toxin (T-2), a trichothecene mycotoxin, into mice induced DNA fragmentation, a biochemical hallmark of apoptosis, in the thymus. In this study, we investigated the effective chemical structure(s) of T-2-derived metabolites capable of inducing...
Topics
- Animals
- Apoptosis
- Chromatography, Gas
- Colorimetry
- DNA Fragmentation
- Electrophoresis, Polyacrylamide Gel
- Female
- Flow Cytometry
- Fusarium
- Mice
- Mice, Inbred BALB C
- Phenotype
- Random Allocation
- Structure-Activity Relationship
- T-2 Toxin
- T-Lymphocytes
- Thymus Gland
- Time Factors