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Article

Fertilization Defects in Sperm from Mice Lacking Fertilin β

18 Sept 1998

Abstract excerpt

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane...

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PMID: 9743500
DOI: 10.1126/science.281.5384.1857

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