Article
Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency.
Nature genetics - 1 Sept 1998
Reiss J, Cohen N, Dorche C, Mandel H, Mendel R R, Stallmeyer B, Zabot M T, Dierks T
Abstract excerpt
All molybdoenzymes other than nitrogenase require molybdopterin as a metal-binding cofactor. Several genes necessary for the synthesis of the molybdenum cofactor (MoCo) have been characterized in bacteria and plants. The proteins encoded by the Escherichia coli genes moaA and moaC catalyse the fi...
Topics
- Amino Acid Sequence
- Base Sequence
- Carbon-Carbon Lyases
- Coenzymes
- Conserved Sequence
- Female
- Humans
- Male
- Metabolism, Inborn Errors
- Metalloproteins
- Molecular Sequence Data
- Molybdenum Cofactors
- Mutation
- Nuclear Proteins
- Open Reading Frames
- Pedigree
- Pteridines
- RNA, Messenger