Cyclical alternative exon splicing of transcription factor cyclic adenosine monophosphate response element-binding protein (CREB) messenger ribonucleic acid during rat spermatogenesis.

Abstract excerpt

During spermatogenesis, the levels of cAMP in seminiferous tubules undergo stage-dependent cyclical fluctuations. We show that changes in cAMP levels are accompanied by alternative exon splicing of the RNA encoding the cAMP-responsive transcription factor CREB (cAMP response element-binding prote...

Topics

• Alternative Splicing
• Animals
• Cyclic AMP Response Element-Binding Protein
• Exons
• Genetic Variation
• Male
• Periodicity
• RNA, Messenger
• Rats
• Rats, Sprague-Dawley
• Spermatogenesis
• Time Factors