Meiotic breakpoint mapping of a proposed X linked visual loss susceptibility locus in Leber's hereditary optic neuropathy.

doi:10.1136/jmg.35.8.668

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Article

Meiotic breakpoint mapping of a proposed X linked visual loss susceptibility locus in Leber's hereditary optic neuropathy.

Journal of medical genetics - 1 Aug 1998

Handoko H Y, Wirapati P J, Sudoyo H A, Sitepu M, Marzuki S

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a maternally inherited degenerative disorder characterised by an acute or subacute optic nerve degeneration resulting in visual failure. Mitochondrial DNA mutations have been reported and a nuclear modifier gene(s) on the X chromosome is thought to pl...

Topics

Adult
Chromosome Breakage
Chromosome Mapping
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Meiosis
Optic Atrophies, Hereditary
Pedigree
X Chromosome

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