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Article

Deletions of 9p and the quest for a conserved mechanism of sex determination.

Molecular genetics and metabolism - 1 Jan 2000

Ottolenghi C, McElreavey K

Abstract excerpt

Distal chromosome 9p contains a locus that, when deleted, is a cause of 46,XY gonadal dysgenesis in the absence of extragenital anomalies. This locus might account for the frequently observed cases of 46,XY pure gonadal dysgenesis who do not harbor mutations in SRY, the sex master regulator gene found in mammalian species. The genomic organization of 9p positional candidate genes is currently being studied and...

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Topics

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Share to Chromosome Deletion
Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Gene Expression Regulation, Developmental

Share to Gonadal Dysgenesis, 46,XY

Share to Sequence Homology, Amino Acid

Share to Sex Determination Processes

Source

Identifiers

PMID: 11001833
DOI: 10.1006/mgme.2000.3060

Genes

DMRT1
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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