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Article

Horizontal Genetic Exchange, Evolution, and Spread of Antibiotic Resistance in Bacteria

1 Aug 1998

Abstract excerpt

Some transformable bacteria have acquired target-mediated antibiotic resistance by horizontal genetic exchange of fragments of chromosomal genes. The resistant strains express variants of the antibiotic target that are metabolically active but exhibit a lowered affinity for the antibiotic. The alleles encoding these resistant proteins are mosaics comprising DNA derived from the host and other bacteria, often...

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PMID: 9710667
DOI: 10.1086/514917

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