Recent discoveries in cancer genetics of exocrine pancreatic neoplasia.

Abstract excerpt

Within the past 4 years major advances in our understanding of pancreatic carcinogenesis have been made. The discovery of a high frequency of mutations in the tumor suppressor genes p16 and p53 together with an extraordinary high rate of K-ras mutations have shed light on how the disturbance of cell cycle control is a major hallmark in this tumor type. Furthermore, another very recently identified tumor...

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