Article
Absence of linkage between MHC and a gene involved in susceptibility to human schistosomiasis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 May 1998
Chiarella J M, Goldberg A C, Abel L, Carvalho E M, Kalil J, Dessein A
Abstract excerpt
Six hundred million people are at risk of infection by Schistosoma mansoni. MHC haplotypes have been reported to segregate with susceptibility to schistosomiasis in murine models. In humans, a major gene related to susceptibility/resistance to infection by S. mansoni (SM1) and displaying the mean fecal egg count as phenotype was detected by segregation analysis. This gene displayed a codominant mode of...
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