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Article

The thrifty-genotype hypothesis and its implications for the study of complex genetic disorders in man.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 1998

Sharma A M

Abstract excerpt

According to the "thrifty-genotype" hypothesis proposed by Neel, diseases of civilization such as non-insulin-dependent diabetes mellitus and hypertension result from a discordance between certain features of our present-day environment and our genetic make-up which evolved to fit the life of Paleolithic humans. This concept implies that while "affected" individuals harbor the "original" ancestral version of the...

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Source

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PMID: 9694433
DOI: 10.1007/s001090050251

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AGT

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