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Article

The thrifty-genotype hypothesis and its implications for the study of complex genetic disorders in man.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 1998

Sharma A M

Abstract excerpt

According to the "thrifty-genotype" hypothesis proposed by Neel, diseases of civilization such as non-insulin-dependent diabetes mellitus and hypertension result from a discordance between certain features of our present-day environment and our genetic make-up which evolved to fit the life of Pal...

Topics

Angiotensinogen
Animals
Biological Evolution
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Genetic Variation
Hominidae
Humans
Hypertension
Primates

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9694433
DOI: 10.1007/s001090050251

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9694433-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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