Reversal of convention: from man to experimental animal in elucidating the function of the renal amiloride-sensitive sodium channel.

doi:10.1159/000020531

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Article

Reversal of convention: from man to experimental animal in elucidating the function of the renal amiloride-sensitive sodium channel.

Experimental nephrology - 1 Jan 2000

Hummler E

Abstract excerpt

The kidney plays a dominant role in maintaining sodium homeostasis. Despite wide variation in environmental exposure, the osmolality of the extracellular fluid that is determined by the sodium ion concentration is maintained within narrow margins. Derangement in function of proteins that transpor...

Topics

Amiloride
Animals
Chromosome Mapping
Disease Models, Animal
Gene Targeting
Homeostasis
Humans
Hypertension
Kidney
Mutation
Sodium Channels

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