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Article

Encapsidation studies of poliovirus subgenomic replicons.

1 Jul 1998

Abstract excerpt

The inclusion of a foreign marker gene, chloramphenicol acetyltransferase (CAT) gene, into the poliovirus genome allows its replication and encapsidation to be easily monitored using a simple enzyme assay. Such poliovirus replicons require the presence of helper virus for their successful propagation and thus are similar to defective interfering (DI) viruses. In genomes containing the CAT gene, the majority of...

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PMID: 9680136
DOI: 10.1099/0022-1317-79-7-1725

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