Article
Models for haplotype evolution in a nonstationary population.
Theoretical population biology - 1 Jun 1998
Fan R, Lange K
Abstract excerpt
Haplotype mapping has emerged in the past few years as a powerful tool for the fine mapping of disease genes. It is typically carried out on a sample of affected individuals from a population isolate. If the chromosome neighborhood of a disease gene is saturated with markers, then each new mutati...
Topics
- Biological Evolution
- Chromosome Mapping
- Finland
- Founder Effect
- Genes, Dominant
- Genetic Diseases, Inborn
- Genetic Markers
- Haplotypes
- Humans
- Models, Genetic
- Mutation
- Recombination, Genetic
- Selection, Genetic
- Stochastic Processes