Article
Patients with features similar to Huntington's disease, without CAG expansion in huntingtin.
Neurology - 1 Jul 1998
Rosenblatt A, Ranen N G, Rubinsztein D C, Stine O C, Margolis R L, Wagster M V, Becher M W, Rosser A E, Leggo J, Hodges J R, ffrench-Constant C K, Sherr M, Franz M L, Abbott M H, Ross C A
Abstract excerpt
OBJECTIVE: To describe characteristics of gene-negative patients with clinical features of Huntington's disease (HD), exploring likely etiologies. BACKGROUND: When a direct gene test became definitive for diagnosis of HD, we discovered a number of patients in our clinics in Baltimore, MD, and Cam...
Topics
- Adult
- Brain Chemistry
- Cohort Studies
- Family Health
- Female
- Humans
- Huntingtin Protein
- Huntington Disease
- Magnetic Resonance Imaging
- Male
- Mutation
- Nerve Tissue Proteins
- Nuclear Proteins
- Pedigree