Article
Differential diagnosis of hereditary hemochromatosis from other liver disorders by genetic analysis: gene mutation analysis of patients previously diagnosed with hemochromatosis by liver biopsy.
Archives of pathology & laboratory medicine - 1 Jul 1998
Bartolo C, McAndrew P E, Sosolik R C, Cawley K A, Balcerzak S P, Brandt J T, Prior T W
Abstract excerpt
BACKGROUND: Hereditary hemochromatosis, a common autosomal recessive trait caused by mutations in the HLA-H gene, is often diagnosed by the pathologist at the time of histologic examination. Unfortunately, histologic parameters alone do not differentiate between hereditary hemochromatosis and oth...
Topics
- Adult
- Aged
- Biopsy
- DNA Mutational Analysis
- Diagnosis, Differential
- Electrophoresis, Polyacrylamide Gel
- Female
- Hemochromatosis
- Heterozygote
- Homozygote
- Humans
- Liver Diseases
- Male
- Middle Aged
- Mutation
- Pedigree
- Polymerase Chain Reaction