Threshold expression of the tRNA(Lys) A8344G mutation in single muscle fibres.

doi:10.1016/s0960-8966(98)00029-7

Back to search

Article

Threshold expression of the tRNA(Lys) A8344G mutation in single muscle fibres.

Neuromuscular disorders : NMD - 1 Jun 1998

Moslemi A R, Tulinius M, Holme E, Oldfors A

Abstract excerpt

We investigated the distribution in skeletal muscle of mitochondrial DNA (mtDNA) with the tRNA(Lys) A8344G mutation, which is associated with myoclonus epilepsy and ragged red fibres (MERRF) syndrome. Isolated muscle fibre segments (n = 144) from six individuals of two different families carrying...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
DNA, Mitochondrial
Electron Transport Complex IV
Female
Histocytochemistry
Humans
Male
Muscle Fibers, Skeletal
Mutation
Pedigree
Polymerase Chain Reaction
RNA, Transfer, Lys

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.