Mutagenesis of outer membrane virulence determinants of the oral spirochete Treponema denticola.

doi:10.1111/j.1574-6968.1998.tb13047.x

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Article

Mutagenesis of outer membrane virulence determinants of the oral spirochete Treponema denticola.

FEMS microbiology letters - 15 Jun 1998

Fenno J C, Wong G W, Hannam P M, McBride B C

Abstract excerpt

The pore-forming major surface protein (Msp) and the chymotrypsin-like protease (CTLP) of Treponema denticola ATCC 35405 have been implicated in periodontal pathogenicity. Allelic replacement mutations were constructed at two sites in the msp gene and at one site in the CTLP locus. All mutant str...

Topics

Alleles
Bacterial Proteins
Blotting, Southern
Electrophoresis, Polyacrylamide Gel
Humans
Immunoblotting
Microscopy, Electron
Mutation
Periodontal Diseases
Porins
Serine Endopeptidases
Transformation, Bacterial
Treponema
Virulence

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