Article
Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells.
Journal of the National Cancer Institute - 1 Jul 1998
Abbott D W, Freeman M L, Holt J T
Abstract excerpt
BACKGROUND: The protein product of the BRCA2 gene mediates repair of double-strand breaks in DNA. Because a number of cancer therapies exert cytotoxic effects via the initiation of double-strand breaks, cancers comprised of cells carrying BRCA2 gene mutations may be more amenable to treatment wit...
Topics
- Adenocarcinoma
- Antineoplastic Agents
- Breast Neoplasms
- Cell Survival
- DNA Damage
- DNA Primers
- DNA Repair
- DNA, Neoplasm
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Humans
- Mutation
- Neoplasm Proteins
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Time Factors
- Tumor Cells, Cultured