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Article

Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2004

Zhang Zhuo, Wang Hui, Prasad Gautam, Li Mao, Yu Dong, Bonner James A, Agrawal Sudhir, Zhang Ruiwen

Abstract excerpt

PURPOSE: The MDM2 oncogene, amplified or overexpressed in many human cancers, has been suggested to be a novel target for cancer therapy. We have demonstrated a second-generation antisense antihuman-MDM2 oligonucleotide to have antitumor activity when administered alone or in combination with cancer chemotherapeutic agents. In the present study, we investigated the effect of the antisense oligonucleotide on...

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Source

Identifiers

PMID: 14977824
DOI: 10.1158/1078-0432.ccr-0245-03

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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