Article
Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes.
Journal of the National Cancer Institute - 20 May 1998
Brunet J S, Ghadirian P, Rebbeck T R, Lerman C, Garber J E, Tonin P N, Abrahamson J, Foulkes W D, Daly M, Wagner-Costalas J, Godwin A, Olopade O I, Moslehi R, Liede A, Futreal P A, Weber B L, Lenoir G M, Lynch H T, Narod S A
Abstract excerpt
BACKGROUND: Smoking has carcinogenic effects, and possibly antiestrogenic effects as well, but it has not been found to be a risk factor for breast cancer in women in the general population. However, hereditary breast cancer is primarily a disease of premenopausal women, and interactions between genes and hormonal and environmental risk factors may be particularly important in this subgroup. METHODS: We conducted...
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