Unanticipated Inhibition of the Metallo-β-lactamase from <i>Bacteroides </i><i>f</i><i>ragilis</i> by 4-Morpholineethanesulfonic Acid (MES):  A Crystallographic Study at 1.85-Å Resolution

Abstract excerpt

As part of a structure-aided effort to design clinically useful inhibitors of metallo-beta-lactamases, the X-ray crystal structure of a complex between the metallo-beta-lactamase from Bacteroides fragilis and 4-morpholinoethanesulfonic acid (MES) has been determined and a model for the structure has been refined to a crystallographic R-factor of 0.151 for data between 10.0- and 1.85-A resolution. Although the...

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