Article
DNA-EIA to detect high and low risk HPV genotypes in cervical lesions with E6/E7 primer mediated multiplex PCR.
Journal of clinical pathology - 1 Jan 1998
Clavel C, Rihet S, Masure M, Chypre C, Boulanger J C, Quereux C, Birembaut P
Abstract excerpt
BACKGROUND: Oncogenicity of human papillomavirus (HPV) DNA in premalignant and malignant uterine cervical diseases is mainly induced by E6/E7 open reading frame (ORF). The presence of an oncogenic HPV DNA may be a diagnostic marker for the detection of cytologically negative smears. AIMS: To eval...
Topics
- Adult
- Biotinylation
- DNA, Viral
- Female
- Genotype
- Humans
- Immunoenzyme Techniques
- Oligonucleotide Probes
- Open Reading Frames
- Papillomaviridae
- Papillomavirus Infections
- Polymerase Chain Reaction
- Sensitivity and Specificity
- Tumor Virus Infections
- Uterine Cervical Neoplasms
