How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.

Article

How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 1998

Mitchison D A

Abstract excerpt

OBJECTIVE: To explore mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy. DESIGN: Four theoretical mechanisms are first described. RESULTS: Examples of the way the mechanisms probably operate are taken from: 1) a study of once-weekly chemotherapy with streptomycin and isoniazid, and 2) the pattern of drug susceptibility in cultures from patients who...

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