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Article

Impact of bacterial biofilm formation on in vitro and in vivo activities of antibiotics.

Antimicrobial agents and chemotherapy - 1 Apr 1998

Schwank S, Rajacic Z, Zimmerli W, Blaser J

Abstract excerpt

The impact of bacterial adherence on antibiotic activity was analyzed with two isogenic strains of Staphylococcus epidermidis that differ in the features of their in vitro biofilm formation. The eradication of bacteria adhering to glass beads by amikacin, levofloxacin, rifampin, or teicoplanin was studied in an animal model and in a pharmacokinetically matched in vitro model. The features of S. epidermidis RP62A...

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Identifiers

PMID: 9559803
DOI: 10.1128/AAC.42.4.895
PMCID: PMC105562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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