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Article

Forced evolution reveals the importance of short open reading frame A and secondary structure in the cauliflower mosaic virus 35S RNA leader.

Journal of virology - 1 May 1998

Pooggin M M, Hohn T, Fütterer J

Abstract excerpt

Cauliflower mosaic virus pregenomic 35S RNA begins with a long leader sequence containing an extensive secondary structure and up to nine short open reading frames (sORFs), 2 to 35 codons in length. To test whether any of these sORFs are required for virus viability, their start codons were mutated either individually or in various combinations. The resulting viral mutants were tested for infectivity on...

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Identifiers

PMID: 9557705
DOI: 10.1128/JVI.72.5.4157-4169.1998
PMCID: PMC109645

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