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Article

Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome.

Human genetics - 1 Mar 1998

Satler C A, Vesely M R, Duggal P, Ginsburg G S, Beggs A H

Abstract excerpt

Long QT syndrome (LQTS), is an inherited cardiac disorder in which ventricular tachyarrhythmias predispose affected individuals to syncope, seizures, and sudden death. Characteristic electrocardiographic findings include a prolonged QT interval, T wave alternans, and notched T waves. We have scre...

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Source

Identifiers

PMID: 9544837
DOI: 10.1007/s004390050690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9544837-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome.PMID 9544837Read ↗

Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel.Semantic proximity Read ↗

Missense mutation in the pore region of HERG causes familial long QT syndrome.Semantic proximity Read ↗

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.Semantic proximity Read ↗

Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome.Semantic proximity Read ↗

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.Semantic proximity Read ↗

Homozygosity for a HERG potassium channel mutation causes a severe form of long QT syndrome: identification of an apparent founder mutation in the Finns.Semantic proximity Read ↗

Survey of the coding region of the HERG gene in long QT syndrome reveals six novel mutations and an amino acid polymorphism with possible phenotypic effects.Semantic proximity Read ↗

Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome.Semantic proximity Read ↗

A novel splice mutation of HERG in a Chinese family with long QT syndrome.Semantic proximity Read ↗

Novel KCNQ1 and HERG missense mutations in Dutch long-QT familiesSemantic proximity Read ↗

Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel.Semantic proximity Read ↗

KVLQT1 mutations in three families with familial or sporadic long QT syndrome.Semantic proximity Read ↗

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