Article
Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene.
The Journal of investigative dermatology - 1 Apr 1998
Pack S, Turner M L, Zhuang Z, Vortmeyer A O, Böni R, Skarulis M, Marx S J, Darling T N
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1), the heritable tendency to develop tumors of the parathyroid, pituitary, and entero-pancreatic endocrine tissues, is the consequence of a germline mutation in the MEN1 gene. Endocrine tumors in these patients result when the mutant MEN1 allele is accompanied by loss of the normal MEN1 allele. Recently it was reported that MEN1 patients also exhibit several cutaneous...
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