Article
Differences in reverse transcriptase activity versus p24 antigen detection in cell culture, when comparing a homogeneous group of HIV type 1 subtype B viruses with a heterogeneous group of divergent strains.
AIDS research and human retroviruses - 1 Mar 1998
Corrigan G E, Al-Khalili L, Malmsten A, Thorstensson R, Fenyö E M, Källander C F, Gronowitz J S
Abstract excerpt
Failure to detect infection with HIV-1 non-B subtypes in some antibody screening assays has been shown. To date, however, no studies have been published evaluating the capacity of standard tests to quantify replication of divergent HIV-1 in cell culture. Reverse transcriptase (RT) activity and p24 antigen assays are the two methods most commonly used for this purpose. A homogeneous panel of HIV-1 subtype B...
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