Article
Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 1998
den Heijer M, Brouwer I A, Bos G M, Blom H J, van der Put N M, Spaans A P, Rosendaal F R, Thomas C M, Haak H L, Wijermans P W, Gerrits W B
Abstract excerpt
Hyperhomocysteinemia is a risk factor for atherosclerosis and thrombosis and is inversely related to plasma folate and vitamin B12 levels. We assessed the effects of vitamin supplementation on plasma homocysteine levels in 89 patients with a history of recurrent venous thrombosis and 227 healthy volunteers. Patients and hyperhomocysteinemic (homocysteine level >16 micromol/L) volunteers were randomized to placebo...
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