Article
Two siblings with classical xanthinuria type 1: significance of allopurinol loading test.
Internal medicine (Tokyo, Japan) - 1 Jan 1998
Ichida K, Yoshida M, Sakuma R, Hosoya T
Abstract excerpt
Two brothers with classical xanthinuria who lacked xanthine dehydrogenase activity were encountered. Their hypouricemia was caused by underproduction of uric acid. In their duodenal mucosa, no xanthine dehydrogenase (oxidase) activity was detected. The patients had no symptoms except for duodenal ulcer in one case. The conversion of allopurinol to oxipurinol during an allopurinol loading test for determining the...
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