Pleiotropy and the preservation of perfection.

Article

Pleiotropy and the preservation of perfection.

Science (New York, N.Y.) - 20 Feb 1998

Waxman D, Peck J R

Abstract excerpt

A mathematical model is presented in which a single mutation can affect multiple phenotypic characters, each of which is subject to stabilizing selection. A wide range of mutations is allowed, including ones that produce extremely small phenotypic changes. The analysis shows that, when three or m...

Topics

Animals
Codon
Genetic Variation
Genetics, Population
Genotype
Models, Genetic
Mutation
Phenotype
Probability
Proteins
Selection, Genetic

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