Article
Use of concanavalin A to analyse the mechanism of memory cell differentiation into killer cells.
Annales d'immunologie - 1 Jan 2000
Reme T X, Dupuy d'Angeac A, Radal M, Serrou B
Abstract excerpt
The renewing by ConA of the cytolytic activity evaluated in a short-term chromium release assay in a population of memory cells obtained in a long-term mixed lymphocyte culture is shown to be largely dependent upon the dose of ConA used; a three staged phenomenon in terms of dose response and kinetics is analysed and suggests that at least for low concentration of ConA (0.5 micrograms/ml) the lectin acts on the...
Topics
- Animals
- Binding, Competitive
- Cell Differentiation
- Concanavalin A
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Immunologic
- Epitopes
- Immunologic Memory
- Killer Cells, Natural
- Kinetics
- Lymphocyte Culture Test, Mixed