Article
Quantitative ELISA for platelet m-calpain: a phenotypic index for detection of carriers of Duchenne muscular dystrophy.
Clinica chimica acta; international journal of clinical chemistry - 12 Jan 1998
Hussain T, Kumar D V, Sundaram C, Mohandas S, Anandaraj M P
Abstract excerpt
In order to measure the amount of m-calpain in platelets from Duchenne muscular dystrophy (DMD) patients, carriers and controls, an enzyme linked immunosorbent assay (ELISA) has been developed using polyclonal antibodies raised against m-calpain (Calcium dependent neutral protease), purified from human placenta. Compared to controls a nine-fold increase in the level of m-calpain was observed in all 25 DMD...
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