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Engineering a Human Bone Marrow Model: A Case Study on ex Vivo Erythropoiesis

6 Feb 1998

Abstract excerpt

Bone marrow, with its intricate, three-dimensional tissue structure facilitating cell-cell interactions, provides a microenvironment supporting the production of hundreds of billions of multilineal blood cells everyday. We have developed a three-dimensional bone marrow culture system in which marrow cells are cultured in a reactor packed with porous microspheres. The culture supports a three-dimensional growth...

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PMID: 9496677
DOI: 10.1021/bp970136+

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