Article
Identification of a Val 145 Ile substitution in the human myelin oligodendrocyte glycoprotein: lack of association with multiple sclerosis. The Réseau de Recherche Clinique INSERM sur la Susceptibilité Génétique à la Sclérose en Plaques.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 1997
Rodriguez D, Della Gaspera B, Zalc B, Hauw J J, Fontaine B, Edan G, Clanet M, Dautigny A, Pham-Dinh D
Abstract excerpt
Myelin/oligodendrocyte glycoprotein (MOG) is a major target antigen in experimental autoimmune encephalomyelitis and it has been suggested that it may as well play a key role in the demyelination process in multiple sclerosis (MS). As MOG variants could be pathogenic in autoimmune demyelinating diseases of the central nervous system, we analysed the coding sequence of MOG in MS patients and described a G-->A...
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