Article
ASSOCIATION STUDY OF THE 5’ FLANKING REGIONS OF ENDOTHELIAL‐NITRIC OXIDE SYNTHASE AND ENDOTHELIN‐1 GENES IN FAMILIAL PRIMARY OPEN‐ANGLE GLAUCOMA
1 Jan 1998
Abstract excerpt
1. Endothelium-derived substances are important regulators of the microcirculation. Endothelium-derived nitric oxide (NO), which is catalysed by nitric oxide synthase (NOS), is a potent modulator of vascular tone in the human ophthalmic artery, which is normally in a state of constant vasodilation due to the actions of NO. Endothelin-1 (ET-1) produces vasoconstriction of the anterior optic nerve vasculature and...
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