Article
Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele.
Atherosclerosis - 1 Dec 1997
Abdel-Wareth L O, Pimstone S N, Lagarde J P, Raisonnier A, Benlian P, Pritchard H, Hayden M R, Frohlich J J
Abstract excerpt
Familial defective apo B-100 (FDB) is an autosomal dominant condition resulting in hypercholesterolemia. It is generally observed in 1-6% of hypercholesterolemic subjects in Caucasian populations studied. There are, thus far, no reports characterizing the frequency and phenotype of FDB in a Chinese population. We report on the frequency of the FDB (Arg(3500)--> Gln) mutation and the associated haplotype among 160...
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