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Article

Identification and haplotype analysis of apolipoprotein B-100 Arg3500-->Trp mutation in hyperlipidemic Chinese.

Clinical chemistry - 1 Aug 1998

Tai D Y, Pan J P, Lee-Chen G J

Abstract excerpt

DNA screening for apolipoprotein (apo) B-100 mutations was performed in hyperlipidemic Chinese. The apo B-100 gene segment surrounding previously identified familial defective apo B-100 (FDB) mutations was amplified by PCR and subjected to single-strand conformation polymorphism (SSCP) analysis. One subject's aberrant SSCP band was cloned and sequenced to study the molecular lesions. A recurrent ArgCGG-to-TrpTGG...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Amino Acid Substitution
Apolipoprotein B-100
Apolipoproteins B
Arginine
Female
Genetic Carrier Screening
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyperlipidemias

Lipoproteins

Male

Middle Aged

Mutation

Pedigree

Source

Identifiers

PMID: 9702952

Provenance

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Identification and haplotype analysis of apolipoprotein B-100 Arg3500-->Trp mutation in hyperlipidemic Chinese.PMID 9702952Read ↗

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