Article
Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana.
Nucleic acids research - 15 Jan 1998
Nakajima S, Sugiyama M, Iwai S, Hitomi K, Otoshi E, Kim S T, Jiang C Z, Todo T, Britt A B, Yamamoto K
Abstract excerpt
UV radiation induces two major classes of pyrimidine dimers: the pyrimidine [6-4] pyrimidone photoproduct (6-4 product) and the cyclobutane pyrimidine dimer (CPD). Many organisms produce enzymes, termed photolyases, that specifically bind to these damage products and split them via a UV-A/blue light-dependent mechanism, thereby reversing the damage. These photolyases are specific for either CPDs or 6-4 products....
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