Article
A gene (ETM) for essential tremor maps to chromosome 2p22-p25.
Movement disorders : official journal of the Movement Disorder Society - 1 Nov 1997
Higgins J J, Pho L T, Nee L E
Abstract excerpt
We report the results of linkage analysis in a large American family of Czech descent with dominantly inherited "pure" essential tremor (ET) and genetic anticipation. Genetic loci on chromosome 2p22-p25 establish linkage to this region with a maximum LOD score (Zmax) = 5.92 for the locus, D2S272. Obligate recombinant events place the ETM gene in a 15-cM candidate interval between the genetic loci D2S168 and...
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