Article
ENU-induced late-onset night blindness associated with rod photoreceptor cell degeneration in zebrafish.
Mechanisms of ageing and development - 1 Dec 2003
Maaswinkel Hans, Mason Bryan, Li Lei
Abstract excerpt
We describe a dominant mutation, night blindness d (nbd), that causes late-onset rod photoreceptor cell degeneration in zebrafish. The mutation was induced by treating male zebrafish with N-ethyl-N-nitrosourea (ENU). Visual sensitivity was tested using a behavioral assay based on a visually mediated escape response. At a young age, the heterozygous (nbd+/-) fish did not show any signs of night blindness or...
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