Article
Permeation of antimicrobial agents through Pseudomonas aeruginosa biofilms: a simple method.
Chemotherapy - 1 Jan 2000
Shigeta M, Tanaka G, Komatsuzawa H, Sugai M, Suginaka H, Usui T
Abstract excerpt
In this study, we evaluated the permeation of piperacillin (PIPC), imipenem (IPM), amikacin (AKM), gentamicin (GM), ofloxacin (OFLX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sparfloxacin (SPFX) through Pseudomonas aeruginosa biofilm with a simple new method. Bacteria used were a leucine-requiring mucoid mutant. Bacteria were grown on the membrane of a cell culture insert in chemically defined medium and...
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