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Article

High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms.

Antimicrobial agents and chemotherapy - 1 Jan 2013

Hengzhuang Wang, Ciofu Oana, Yang Liang, Wu Hong, Song Zhijun, Oliver Antonio, Høiby Niels

Abstract excerpt

Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in the pharmacokinetics (PK) and pharmacodynamics (PD) of ceftazidime and imipenem on P. aeruginosa...

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Identifiers

PMID: 23089750
DOI: 10.1128/AAC.01393-12
PMCID: PMC3535908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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