Article
Preimplantation genetic diagnosis: current status and new developments.
Human reproduction (Oxford, England) - 1 Aug 1997
Lissens W, Sermon K
Abstract excerpt
Preimplantation genetic diagnosis (PGD) is a very early form of prenatal diagnosis aimed at eliminating embryos carrying serious genetic diseases before implantation. To this end, two major technologies are in use: the polymerase chain reaction (PCR) for monogenic diseases and fluorescent in-situ hybridization (FISH) for chromosomal aberrations. In this review, a number of problems arising from the use of these...
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