Association of genetic variations in apolipoprotein B with hypercholesterolemia, coronary artery disease, and receptor binding of low density lipoproteins.

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Article

Association of genetic variations in apolipoprotein B with hypercholesterolemia, coronary artery disease, and receptor binding of low density lipoproteins.

Journal of lipid research - 1 Jul 1997

Ludwig E H, Hopkins P N, Allen A, Wu L L, Williams R R, Anderson J L, Ward R H, Lalouel J M, Innerarity T L

Abstract excerpt

To search for unique mutations in the apolipoprotein B (apoB) gene that disrupt the binding of LDL to its receptor and cause hypercholesterolemia, we examined more than 800 patients with high LDL cholesterol levels and/or coronary artery disease (CAD). Analysis of patient DNA by single-strand con...

Topics

Adult
Aged
Apolipoproteins B
Binding, Competitive
Cholesterol
Cholesterol, LDL
Coronary Disease
Female
Genetic Variation
Genotype
Humans
Hypercholesterolemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins, LDL

Male

Middle Aged

Pedigree

Polymorphism, Single-Stranded Conformational

Receptors, LDL

Source

Open in PubMed

Identifiers

PMID: 9254062

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9254062-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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