Article
Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease.
Gastroenterology - 1 Aug 1997
Mansouri A, Gaou I, Fromenty B, Berson A, Lettéron P, Degott C, Erlinger S, Pessayre D
Abstract excerpt
BACKGROUND & AIMS: Aging is associated with and may be caused by acquired somatic mutations of the mitochondrial genome. In Wilson's disease, inherited mutations of a nuclear gene encoding a copper transporter cause accumulation of copper in the liver, particularly within mitochondria. Because copper has prooxidant properties and the mitochondrial genome is particularly susceptible to oxidative damage, we...
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