Article
Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2005
Ferenci Peter, Steindl-Munda Petra, Vogel Wolfgang, Jessner Wolfgang, Gschwantler Michael, Stauber Rudolf, Datz Christian, Hackl Franz, Wrba Fritz, Bauer Peter, Lorenz Oskar
Abstract excerpt
BACKGROUND & AIMS: A 5-fold increase of hepatic copper concentration is considered as the best available test for diagnosis of hepatic Wilson's disease (WD). However, the sensitivity and specificity of this test have never been fully investigated. METHODS: Copper content was measured by flame atomic absorption spectroscopy in 114 liver biopsies obtained at diagnosis of WD, in 219 patients with noncholestatic...
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