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Article

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

5 Aug 1997

Abstract excerpt

The recurring translocation t(11;16)(q23;p13.3) has been documented only in cases of acute leukemia or myelodysplasia secondary to therapy with drugs targeting DNA topoisomerase II. We show that the MLL gene is fused to the gene that codes for CBP (CREB-binding protein), the protein that binds specifically to the DNA-binding protein CREB (cAMP response element-binding protein) in this translocation. MLL is fused...

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Identifiers

PMID: 9238046
DOI: 10.1073/pnas.94.16.8732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)PMID 9238046Read ↗

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NovelMLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocationSemantic proximity Read ↗

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Chromatin‐related properties of CBP fused to MLL generate a myelodysplastic‐like syndrome that evolves into myeloid leukemiaSemantic proximity Read ↗

Identification of CBL, a proto‐oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemiaSemantic proximity Read ↗

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Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3.Semantic proximity Read ↗

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Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype.Semantic proximity Read ↗

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