Article
Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3.
Genomics - 15 May 1997
Giles R H, Petrij F, Dauwerse H G, den Hollander A I, Lushnikova T, van Ommen G J, Goodman R H, Deaven L L, Doggett N A, Peters D J, Breuning M H
Abstract excerpt
In the interest of cloning and analyzing the genes responsible for two very different diseases, the Rubinstein-Taybi syndrome (RTS) and acute myeloid leukemia (AML) associated with the somatic translocation t(8;16)(p11;p13.3), we constructed a high-resolution restriction map of contiguous cosmids (contig) covering 1.2 Mb of chromosome 16p13.3. By fluorescence in situ hybridization and Southern blot analysis, we...
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